Abstract
Cardio-cerebrovascular diseases caused by chronic inflammatory atherosclerosis seriously damage human health. Nano-photothermal technology has been proven to inhibit the development of vascular inflammation, but the currently reported photothermal agents cannot efficient monitor it during the development of the disease. Herein, we designed and prepared an efficient bifunctional nanoplatform for CT imaging guided photothermal therapy of arterial inflammation. Cu3BiS3 nanocrystals with a size of about 12 nm were synthesized by a simple hydrothermal method. The as-prepared Cu3BiS3 nanocrystals showed intense absorption in the NIR region, thus exhibited amazing photothermal effect. The photothermal conversion efficiency of Cu3BiS3 nanocrystals was reach up to 58.6% under the excitation of an 808 nm laser with a power density of 0.4 W cm–2. Cu3BiS3 nanocrystals can efficiently kill the macrophages both in vitro and in vivo, which plays an important role in the development of atherosclerosis, thus can be used as an effective way to inhibit the occurrence of hypertension. Importantly, Cu3BiS3 nanocrystals can be used as an efficient CT contrast agent to monitor carotid inflammation. Our work provides an insight for imaging guided photothermal therapy of arterial inflammation.
Highlights
Atherosclerosis (AS) is one of the cardiovascular diseases which are the leading cause of human death (Libby et al, 2011; Tzoulaki et al, 2016)
What’s more, Cu3BiS3 nanocrystals can efficiently kill the macrophages both in vitro and in vivo, which plays an important role in the development of atherosclerosis, can be used as an effective way to inhibit the occurrence of hypertension
Cu3BiS3 nanocrystals can be used as an efficient CT contrast agent for carotid inflammation
Summary
Atherosclerosis (AS) is one of the cardiovascular diseases which are the leading cause of human death (Libby et al, 2011; Tzoulaki et al, 2016). During the progression of atherosclerosis, massive infiltration of monocytes/macrophages and other inflammatory cells and the pathological proliferation of vascular smooth muscle cells promotes plaque formation, secondary stenosis and even occlusion, leading to the occurrence of ischemic diseases (Wang et al, 2019; Zhang et al, 2019). Hyperthermia can be used to inhibit or kill the aforementioned pathologically expanded cells. This minimally invasive technique is widely used in the treatment of cancer, there are few reports on its application to atherosclerosis, and the application of photothermal therapy technology to atherosclerosis has important research significance
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