Abstract
Based on the resonance energy transfer between CdS@CeO2 and Cu2O@PdAg, a quenching immunosensor for sensitive detection of prostate specific antigen (PSA) was constructed. The CdS@CeO2 heterostructure was obtained by in situ growth of CeO2 particles on the surface of CdS nanorods, and stable cathodic ECL emission was achieved usingK2S2O8 as coreactant. Cu2O@PdAg was composed of Cu2O with tetradecahedral structure and bimetallic PdAg nanospheres and has a UV-V is absorption range between 600 and 800nm. It overlaps with the ECL emission spectrum of CdS@CeO2, realizing the effective quenching of the ECL signal, which provides feasibility for subsequent practical application. The immunosensor exhibited good linearity in the concentration range 10fg·mL-1 ~ 100ng·mL-1, with a detection limit of5.6fg·mL-1. In sample analysis, the recoveries were 99.8-101%, and the relative standard deviation (RSD) was 0.85-1.6% showing great potential and development value for the sensitive detection of prostate cancer.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
