Cu- Zeolitic Imidazolate Framework-8 Loaded on Magnetic Nanofiber as a High-efficient Antimicrobial Scaffold

Abstract

In this work, CoFe2O4 was synthesized as magnetic agent and blended with chitosan-poly vinyl alcohol (CS-PVA) to fabricate magnetic nanofiber (MNF) by electrospinning method. Zeolitic imidazolate framework-8 (ZIF-8) crystals were used as a porous media to prepare MNF@ZIF-8 nanocomposite. Two different methods were employed for doping copper ions into the MNF@ZIF-8 structure by adsorption and encapsulation procedures. Characterization clarification of as synthesis materials were performed. Mechanical tests showed that magnetic nanoparticles caused to improve tension resistance of CS-PVA nanofibrous scaffold. Antimicrobial tests for the prepared materials were done in against two types of Gram-positive and Gram-negative strains. The inhibition zone diameter values for Cu2+ adsorbed-MNF@ZIF-8 (33 mm and 24 mm for E.coli and S.aureus, respectively) were better than that of Cu2+ encapsulated-MNF@ZIF-8 (32 mm and 18 mm for E.coli and S.aureus, respectively). The obtained results showed that the prepared copper doped MNF@ZIF-8 can be potentially used as a scaffold for further investigations in practical wound healing applications.