Cu(OAc)2 mediated mild synthesis of 2-aminobenzimidazoles and 2-aminobenzoxazoles

Abstract

An efficient and facile synthesis for 2-aminobenzimidazoles and 2-aminobenzoxazoles has been reported. Thioureas prepared from the reaction of o-phenylenediamines or 2-aminophenols and isothiocyanate derivatives, underwent desulfurization reaction smoothly under mild conditions in the presence of Cu(OAc)2, and afforded a variety of N-heterocyclic compounds in moderate to good yields.