Abstract
Mononuclear Cu(II) complexes of metformin type biguanidine ligands were prepared in one pot reaction. The bidentate chelating ligands formed in the reaction (in situ) via the nucleophilic addition. The molecular structures of complexes [Cu(L1)2](ClO4)2 and [Cu(L3)2](ClO4)2 were determined by single crystal X-ray diffraction studies. In both structures, each Cu(II) adopts distorted square planar geometry bonded to the imine nitrogen atoms of two bidentate ligands. The DNA binding capacity of the complexes to the FSdsDNA was investigated by UV spectral titrations. The complexes were found to interact with FSdsDNA and the binding constants are comparable to that of ethidium bromide (an intercalating agent). Finally, antibacterial efficiency of the synthesized complexes were tested against gram(+) and gram(−) bacteria. Complexes [Cu(L1)2](ClO4)2 and [Cu(L2)2](ClO4)2 showed considerable activity towards E. coli, S. typhimurium, S. aureus and B. cereus with lower MIC values.
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