Cu(II) complexes of 4- and 5- nitro-substituted heteroaryl cinnamoyl derivatives and determining their anticoagulant activity

Iliana Iliana,Petja Marinova,Neyko Stoyanov,Atanas Dimitrov,Marin Marinov

doi:10.24263/2304-974x-2016-5-2-12

Abstract

Cu(II) complexes of 4- and 5- nitro-substituted heteroaryl cinnamoyl derivatives and determining their anticoagulant activity

Highlights

This article presents the synthesis of Cu(II) complexes of 4- and 5- nitro-substituted heteroaryl cinnamoyl derivatives and the research on their anticoagulant activity
In our previous work [1] we described the synthesis of 4- and 5-nitro-substituted heteroaryl cinnamoyl derivatives from the corresponding 4- and 5-nitro-2-acetyl-1,3indandiones with heteroaldehydes in the presence of pyrrolidine as catalyst
Of particular interest is the nitro group introduced in the phthaloyl ring, due to the strong electron acceptor character due to a significant degree to the change of the distributed electron density, as a result of which change in acidity and other physicochemical properties of 2-acetyl-1,3-indandione can be expected

Summary

Introduction

This article presents the synthesis of Cu(II) complexes of 4- and 5- nitro-substituted heteroaryl cinnamoyl derivatives and the research on their anticoagulant activity. In our previous work [1] we described the synthesis of 4- and 5-nitro-substituted heteroaryl cinnamoyl derivatives from the corresponding 4- and 5-nitro-2-acetyl-1,3indandiones with heteroaldehydes in the presence of pyrrolidine as catalyst. Their structure has been proved by elemental analysis and spectral analysis methods. The compounds were obtained from 4- and 5-nitro-substituted 2-acyl-1,3-indandiones by two different methods: Mosher and Meier [2] and Rotberg and Oshkaya [3], and the new thing in our method was the use of pyrrolidine as catalyst.

Methods

Results

Conclusion