Cu(II) and Zn(II) complexes from a thiosemicarbazone derivative: Investigating the intermolecular interactions, crystal structures and cytotoxicity

Abstract

Two complexes of Cu(II) and Zn(II) were prepared from a thiosemicarbazone derivative (H 2 esct) using their corresponding metal acetates and 2,2′-bipyridine as base. The complexes were characterized by elemental analyses, UV–visible, FT-IR and NMR spectroscopy. The structure of the thiosemicarbazone derivative and its five coordinated complexes were also determined by the single crystal X-ray diffraction study. Copper complex got crystallized in triclinic P 1 ¯ space group and zinc complex in monoclinic P 2 1 / c space group. The crystal structures of the complexes exhibited different types of intermolecular interactions, which have been further analyzed by Hirshfeld surface analysis and fingerprint plots. The in vitro cytotoxicity against Dalton lymphoma ascites cell lines showed that the Zn(II) and Cu(II) complexes are more cytotoxic than their corresponding proligand. • A new thiosemicarbazone and some of its transition metal(II) complexes were synthesized. • The compounds were characterized using spectroscopic techniques such as IR, UV–Vis, NMR etc . • Single crystal X-ray analysis confirmed that during complexation, the ligand acts as tridentate ONS donor forming five coordinateded geometry. • Visual analysis of short contacts was achieved through Hirshfeld surface analysis. • Cu(II) complex exhibited greater cytotoxicity as compared to a standard drug molecule.