Abstract
Recently, graphene oxide (GO) based materials have shown great potential in the treatment of implant bacterial infections due to its inherent antibacterial activity. However, the effect of GO-based materials on biological systems particularly the antibacterial mechanisms is still not clear. In this study, GO, NaBH4 treated GO (GO-Y), copper decorated GO (GO-Cu, GO-Cu-GO) composited coatings were prepared on the surface of silicon dioxide (SiO2) substrate by spin-coating and chemical in-situ formation. The growth of Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus) on GO-Y, GO-Cu, and GO-Cu-GO were significantly inhibited, especially on GO-Cu and GO-Cu-GO coatings. The implied antibacterial mechanism of GO-Cu-Cu coatings was further studied and discussed. The enhanced antibacterial performance of GO-Cu-GO coatings has significant potential application in preventing clinical implant bacterial infections. Moreover, the systematic study of various antibacterial effects also enriches our knowledge of the possible antibacterial mechanisms of graphene-based materials.
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