Cu-catalyzed enantioselective conjugate additions of alkyl zinc reagents to unsaturated N-acyloxazolidinones promoted by a chiral triamide phosphane.

Abstract

A chiral triamide phosphane promotes highly efficient and enantioselective Cu-catalyzed conjugate additions of alkyl zinc compounds to unsaturated oxazolidinones (see scheme). The resulting β-alkyl chiral oxazolidinones are readily converted into synthetically useful carbonyl compounds not accessible by alternative catalytic methods. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2003/z50699_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.