Cu-BTC Metal-Organic Frameworks as Catalytic Modifier for Ultrasensitive Electrochemical Determination of Methocarbamol in the Presence of Methadone

Abstract

In this study, an electrochemical sensor based on copper benzene-1, 3, 5-tricarboxylate (Cu-BTC) metal-organic frameworks (MOF) (Cu-MOF/CPE), in an attempt to modify the carbon paste electrode as a highly sensitive sensor, are synthesized and designed for the simultaneous determination of methocarbamol (METO) in the presence of methadone (META). These drugs have been evaluated because of their impacts on the central nervous system (CNS) and the potential damage which they can cause with overuse or concomitant. The observed responses were recorded by electrochemical techniques such as cyclic voltammetry (CV) and differential pulse voltammetry (DPV). Excellent sensing performance of the suggested electrode was confirmed according to two linear ranges from 0.09 to 100 μM and from 100 to 900 μM with low limit of detection (LOD) of 0.02 μM were achieved for METO analysis, also two linear ranges from 0.08 to 80 μM and from 80 to 800 μM, with low detection limit of 0.05 μM were obtained for META analysis. Several techniques such as scanning electron microscopy (SEM) with energy dispersive X-ray analysis (EDX), X-ray diffraction (XRD) and Fourier-transform infrared spectroscopy (FTIR) and Brunauer–Emmett–Teller (BET) are employed to investigate of copper BTC metal-organic framework structure. The results revealed close packing of hierarchically porous and crystal structure of Cu-BTC MOF. According to results, Cu-BTC MOF was improved the surface area of the modified sensor with significant increase in the oxidation signals owing to their high porosity with remarkable electrochemical properties for measuring these drugs in real samples, including human blood, human urine and tablet.