Abstract
SummaryBackgroundIn this study, we investigated the relationship of adiponectin with bone marker changes in Egyptian children and adolescents with T1DM and the effect of disease duration on these markers, as well as the possible correlations between adiponectin and bone markers in these patients.MethodsSixty Egyptian children and adolescent patients with T1DM were studied. Serum adiponectin and collagen breakdown products (cross-linked C-terminal telopeptide of collagen type l »CTX«) were measured and compared to the results of 20 age-matched healthy controls.ResultsAfter adjustment for age, BMI, Tanner stage and gender; (total) adiponectin was significantly higher in all T1DM patients. Serum level of CTX and 25(OH)D showed a marked decrease in diabetics with disease duration > 5 years. Serum level of (total) calcium and inorganic phosphorus (Pi) did not show significant difference from control. CTX was inversely correlated to FBG and T1DM duration. Pi was inversely, while 25(OH)D was directly correlated to FBG. Total calcium showed an inverse correlation with HbA1c. FBG, TC, TAG, LDL-C were independent predictors of CTX in T1DM.ConclusionsAdiponectin showed no correlation with either CTX or bone homeostatic indices. FBG, TC, TAG, LDL-C were independent predictors of CTX in T1DM. We recommend further investigation of adiponectin isoforms in a population-based study, to establish a good age- and sex-related reference.
Highlights
Diabetes mellitus is the most common endocrine metabolic disorder of childhood
The results of our study showed that there was no significant difference between the diabetic subgroups and the control group concerning gender, Tanner stage, BMI and age (P>0.05)
The serum levels of TAG, HDL-C and LDL-C showed no significant difference between the diabetic subgroups and control group, while serum levels of total cholesterol (TC) were significantly higher in all diabetic subgroups compared to control group (p
Summary
An increased incidence of Type 1 diabetes mellitus »T1DM«, is expected worldwide constitutes about 5–10% of diabetes mellitus cases [1]. It spreads widely all over Egypt, with prevalence of 1.09 per 1000 among school aged children [2]. Cross-linked C-terminal telopeptide of collagen type l »CTX« – a small 12 kDa, trivalent cyclic pyridinium structure – has been extensively used as a surrogate measure of bone resorption. It is released from bone collagen into circulation following its degradation by osteoclasts [6]
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