Abstract
The March 2007 issue of Arthritis Research & Therapy included a research article by Gottenberg et al[1] which reports a failure to confirm our previous study[2] of a genetic association between CTLA4 and primary Sjogrens syndrome (pSS).
Highlights
The March 2007 issue of Arthritis Research and Therapy included a research article by Gottenberg and colleagues [1] that reports a failure to confirm our previous study [2] of a genetic association between CTLA4 and primary Sjögren’s syndrome
The Gottenberg study analysed both CTLA4 CT60 and +49A/G single nucleotide polymorphisms (SNPs). They observed an association with the +49A/G SNP in one primary Sjögren’s syndrome (pSS) cohort; this failed to replicate in a second cohort
The CTLA4 CT60 and +49A/G SNPs are haplotype tags for three common, extended CTLA4 haplotypes [3,4], and the main finding of our study was an association between the +49A:CT60G haplotype and autoantibody positive pSS
Summary
The March 2007 issue of Arthritis Research and Therapy included a research article by Gottenberg and colleagues [1] that reports a failure to confirm our previous study [2] of a genetic association between CTLA4 and primary Sjögren’s syndrome (pSS). Arthritis Research & Therapy 2007, 9:401 (doi:10.1186/ar2196) See related research article by Gottenberg et al, http://arthritis-research.com/content/9/2/R24, and related letter by Miceli-Richard et al, http://arthritis-research.com/content/9/3/402
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