Abstract
Background An aberrant regulation of immunological, metabolic, vascular and endocrine processes leads to obstetric complications, including recurrent pregnancy loss (RPL) [1]. Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) is a negative regulator of T cell activation [2] expressed in placental fibroblasts and may modulate peripheral selftolerance of the allogenic fetus [3,4]. It is a stimulatory molecule involved in T-cell activation at the maternal– fetal interface in women with unexplained pregnancy loss [5,6]. In this study, we investigate the possible associations of Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) gene polymorphisms with idiopathic recurrent pregnancy loss (RPL).
Highlights
An aberrant regulation of immunological, metabolic, vascular and endocrine processes leads to obstetric complications, including recurrent pregnancy loss (RPL) [1]
The distribution of rs231775 (P
Among the six three-locus Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) haplotypes constructed, increased frequency of CGA (P=0.0046), and CAG (P=0.036) haplotypes were seen in RPL cases, conferring disease susceptibility nature to these haplotypes
Summary
An aberrant regulation of immunological, metabolic, vascular and endocrine processes leads to obstetric complications, including recurrent pregnancy loss (RPL) [1]. Cytotoxic T lymphocyte-associated antigen 4 (CTLA-4) is a negative regulator of T cell activation [2] expressed in placental fibroblasts and may modulate peripheral selftolerance of the allogenic fetus [3,4]. It is a stimulatory molecule involved in T-cell activation at the maternal– fetal interface in women with unexplained pregnancy loss [5,6]. Among the six three-locus CTLA-4 haplotypes constructed (rs5742909/rs231775/rs3087243), increased frequency of CGA (P=0.0046), and CAG (P=0.036) haplotypes were seen in RPL cases, conferring disease susceptibility nature to these haplotypes
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