Abstract
CT perfusion data sets are commonly acquired using a temporal resolution of 1 image per second. To limit radiation dose and allow for increased spatial coverage, the reduction of temporal resolution is a possible strategy. The aim of this study was to evaluate the effect of reduced temporal resolution in CT perfusion scans with regard to color map quality, quantitative perfusion parameters, ischemic lesion extent, and clinical decision-making when using DC and MS algorithms. CTP datasets from 50 patients with acute stroke were acquired with a TR of 1 second. Two-second TR datasets were created by removing every second image. Various perfusion parameters (CBF, CBV, MTT, TTP, TTD) and color maps were calculated by using identical data-processing settings for 2-second and 1-second TR. Color map quality, quantitative region-of-interest-based perfusion measurements, and TAR/NVT lesions (indicated by CBF/CBV mismatch) derived from the 2-second and 1-second processed data were statistically compared. Color map quality was similar for 2-second versus 1-second TR when using DC and was reduced when using MS. Regarding quantitative values, differences between 2-second and 1-second TR datasets were statistically significant by using both algorithms. Using DC, corresponding tissue-at-risk lesions were slightly smaller at 2-second versus 1-second TR (P < .05), whereas corresponding NVT lesions showed excellent agreement. With MS, corresponding tissue-at-risk lesions showed excellent agreement but more artifacts, whereas NVT lesions were larger (P < .001) compared with 1-second TR. Therapeutic decisions would have remained the same in all patients. CTP studies obtained with 2-second TR are typically still diagnostic, and the same therapy would have been provided. However, with regard to perfusion quantitation and image-quality-based confidence, our study indicates that 1-second TR is preferable to 2-second TR.
Highlights
ObjectivesThe aim of this study was to evaluate the effect of reduced temporal resolution in CT perfusion scans with regard to color map quality, quantitative perfusion parameters, ischemic lesion extent, and clinical decision-making when using DC and MS algorithms
AND PURPOSE: CT perfusion data sets are commonly acquired using a temporal resolution of 1 image per second
Optimized CTP protocols performed at 80 kV(peak) and 200 mAs5,6 can limit radiation dose, whereas standard multimodal stroke CT (NCCT, CTA, CTP) delivers an effective radiation dose of approximately 9
Summary
The aim of this study was to evaluate the effect of reduced temporal resolution in CT perfusion scans with regard to color map quality, quantitative perfusion parameters, ischemic lesion extent, and clinical decision-making when using DC and MS algorithms. The purpose of our study was to evaluate the feasibility of a reduced TR scan protocol using a 2-second TR versus the standard TR of 1-second, by using 2 different algorithms. The objective of our study was not the verification of lesions indicated by CTP but rather a systematic analysis of qualitative and quantitative comparability of 2-second versus 1-second TR
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