CT perfusion imaging in patients with transient ischemic attack： a prospective case series study

Abstract

Objective To investigate the changes of CT perfusion （CTP） imaging and the risk factors for CTP abnormality in patients with transient ischemic attack （TIA）.Methods TIA patients were enrolled; CTP and CT angiography were performed.The parameter values of cerebral blood flow （CBF）,cerebral blood volume （CBV）,mean transit time （MTT）,and time to peak （TTP） were obtained.CTP abnormalities were identified by comparing the contralateral mirror area.Demography and baseline clinical data were compared in a CTP imaging abnormal group and a normal group.Multivariate logistic regression analysis was used to identify the risk factors for CTP abnormality in patients with TIA.Results A total of 69 patients with TIA were enrolled,and 52 of them had perfusion abnormalities corresponding to clinical symptoms.Their TTP and MTT were prolonged,but the decreased CBF and CBV was not obvious.Multivariate logistic regression analysis showed that the higher National Institutes of Health Stroke Scale （NIHSS） score （odds ratio [OR] 1.991,95% confidence interval [OR] 1.113-3.564; P=0.020）,the longer duration of symptoms （OR 1.062,95% OR 1.013-1.114; P =0.013）,and intracranial vascular stenosis （OR 15.410,95% OR 2.118-112.116; P=0.007） were the independent risk factors for CTP abnormality in patients with TIA.The correlation analysis showed that the prolonged TTP （r =0.389,P =0.001） and MTT （r =0.413,P=0.001） were significantly associated with the NIHSS score.Conclusions TTP and MTT may sensitivity reveal cerebral perfusion abnormalities in patients with TIA.The more severe the disease is,the higher the CTP abnormal rate will be. Key words: Ischemic Attack,Transient; Perfusion Imaging; Tomography,X-Ray Computed; Diffusion Magnetic Resonance Imaging; Cerebral Angiography; Intracranial Arteriosclerosis