CT、MR Features and Pathology of Meningioma -Contrast Study of Uitrastructure and Immunohistochemistry

Abstract

Objective To improve the diagnostic level of meningioma in CT and MR.Methods CT and MR features were analyzed in 515 and 78 of 529 cases,respectively.All were verified by operative pathology and classified according to WHO new classification of meningioma in 1990.Ultrastructure was observed by JEM 100 transmission electron microscop(TMB).6 kinds of tumous immunohistochemistry such as Vimentin,glial fibrillary acidic protein (GFAP),Keratin,S 100 protein,epithelial membranous antigen (EMA) and melanoma antigen(HMB45) were detemined.Results There was close relation between mixed or cystic low density in CT,isointensive signal of long T1 or T2 in MR and ultrastructure as vacuolar like cell and cystic process of microcyctic meningioma in electron microscope (EM).There was marked significance between CT or MR feature in other benign or malignant meningioma and ultrastructure of the tumor in EM.Vementin and EMA in 12 kinds of meningioma by pathological classification were showed positive.Conclusion Ultrastructure and immunohistochemistry of the tumor should be done when meningioma was doubt by CT or MR and diagnosed diffcultly by EM.