Abstract
Background Nearly 12% of Americans suffer from peripheral arterial disease (PAD) and many are not eligible for conventional angioplasty or surgical bypass. Microencapsulated stem cell (SC) therapy offers a novel means to transplant allogeneic SCs to avoid immunorejection and enable image tracking. However, quantitative evaluation of capsule fate is elusive. Here we explore c-arm CT and 19F-MRI for serial evaluation of dual X-ray/MR-visible SC microcapsules (XMRCaps) in a rabbit PAD model.
Highlights
Nearly 12% of Americans suffer from peripheral arterial disease (PAD) and many are not eligible for conventional angioplasty or surgical bypass
In vitro validation studies were performed in a phantom consisting of known quantities of X-ray/MR-visible SC microcapsules (XMRCaps)
C-arm CT images were acquired and reconstructed at 0.46 mm3 voxel size. 19F MRI was acquired with a flexible, 4-channel Tx/Rx 19F coil (3D TrueFISP, Siemens Tim Trio, 4.1 ms TR; 2.0 ms TE; 32 averages) in the coronal plane. 1H MRI was acquired with the system body or body matrix coil
Summary
12% of Americans suffer from peripheral arterial disease (PAD) and many are not eligible for conventional angioplasty or surgical bypass. Microencapsulated stem cell (SC) therapy offers a novel means to transplant allogeneic SCs to avoid immunorejection and enable image tracking. Quantitative evaluation of capsule fate is elusive. We explore c-arm CT and 19F-MRI for serial evaluation of dual X-ray/MR-visible SC microcapsules (XMRCaps) in a rabbit PAD model
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