Abstract
We present a patient with progressive dural calcifications, thickening, and enhancement presumably related to the development of nephrogenic systemic fibrosis (NSF). Head CT demonstrated progressive dural calcifications, whereas MR imaging demonstrated progressive dural thickening and enhancement during a 3-year period in which the patient received several gadolinium-enhanced MR imaging studies. To the best of our knowledge, dural calcifications are the only described intracranial finding of NSF.
Highlights
Nephrogenic systemic fibrosis (NSF), previously referred to as nephrogenic fibrosing dermopathy, is a relatively new, rare systemic condition first described in the literature in 2000.1 NSF occurs only in people with renal disease, with more than 215 documented cases in the NSF Registry at Yale University.[2]
NSF is a rare, systemic disease linked to patients with renal failure who are exposed to intravenous gadolinium contrast
Serologic markers of scleroderma including antinuclear antibodies, anti-Scl 70 antibodies, and anticentromere antibodies are absent in NSF.[10]
Summary
Nephrogenic systemic fibrosis (NSF), previously referred to as nephrogenic fibrosing dermopathy, is a relatively new, rare systemic condition first described in the literature in 2000.1 NSF occurs only in people with renal disease, with more than 215 documented cases in the NSF Registry at Yale University.[2] All but a few of the known cases have been associated with intravenous administration of gadolinium-based contrast material.[3] Manifestations of the disease are primarily cutaneous, but multiorgan system involvement has been described.[4,5,6,7] Dural involvement has been described at autopsy; the depiction of the progressive imaging changes has not been documented.[4,6,8] We report a patient with progressive dural calcification, thickening, and enhancement as a manifestation of NSF
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