Abstract
合成了以壳聚糖（CS）为主链、聚（ L -谷氨酸）（PLGA）为侧链的接枝型聚两性电解质CS- g -PLGA（CGA），表征了其结构与组成，探讨了pH值、离子强度和离子种类等对CGA水溶液性质的影响.研究发现，随着溶液离子强度的增大，CGA的等电点（IEP）移向高pH值；离子水化半径越大，对CGA分子中相反电荷的屏蔽作用越弱，对IEP的影响越小；CGA中氨基和羧基相对含量越接近，对溶液离子强度的变化越敏感.此外，CGA具有显著的pH响应性，在酸性及碱性溶液中分别形成结构相反的聚集体.在CS主链氨基含量相近的条件下，聚集体的稳定性随PLGA链长的增加而提高.酸性溶液中聚集体粒径取决于CS主链的电荷数；碱性溶液中PLGA侧链越长则平均粒径越大.
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