Abstract
Activities of the lysosomal enzymes, β-hexosaminidase, α-Mannosidase, acid phosphatase, α-fucosidase and β-glucuronidase in cerebrospinal fluid (CSF) were studied in controls, patients with central nervous system (CNS) damage, and patients with leukaemia. Activities were markedly increased in patients with acute CNS disease. Activity levels in patients with leukaemia were in the normal range whether during induction with intrathecal chemotherapy or cranial irradiation or off treatment. These results suggest that lysosomal enzyme activities in CSF may not provide a sensitive enough marker of CNS damage following induction therapy in leukaemia. Acute leukaemia, cerebrospinal fluid, lysosomal enzymes.
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