CSF inflammatory profile in clinically isolated syndrome and definite multiple sclerosis patients

Abstract

Clinically isolated syndrome (CIS) characterizes the first episode of multiple sclerosis (MS). IgG oligoclonal bands (OCBs) and high levels of inflammatory factors in CSF represent promising biochemical markers of CIS and MS. Here we evaluated the levels of a complex panel of CSF inflammatory mediators in CIS and relapsing-remitting MS (RRMS) patients at time of diagnosis, both with and without OCB, compared with a control group.