Abstract
When men speak of the future, the gods laugh. -Chinese Proverb That noise you’re hearing as you read this article is probably the gods having a jolly old time at my expense. As that great American philosopher and poet Yogi Berra was fond of reminding us, it’s tough to make predictions, especially about the future. Still, that hasn’t prevented fortune-tellers and stock analysts from making a comfortable living doing it. And as far as short-term predictions go, it isn’t as hard as Berra suggests. To a first approximation, tomorrow is usually a lot like today, so we can start by guessing that X-ray diffraction during the next five to 10 years is probably going to resemble its present state, only more so. That means more membrane protein structures, more structures of big assemblies, and more use of structural information in the design of drugs and novel proteins. It also means ...
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