Abstract
Particle shape and size have an influence on the solubility of an API-particle and hence on the bioavailability of the substance. [...]
Highlights
[1] Eder R, Radl S, Schmitt E, Innerhofer S, Maier M, Gruber-Woelfler H, Khinast J
Downstream processes (e. g., filtering, washing, drying etc.) and the handling abilities (e. g., flowability, tabletability) of the particles are positively affected by narrow crystal size distribution (CSD)
Continuously operated tubular crystallizer system, which is based on the growth of seeds to product particles in a tube
Summary
[1] Eder R, Radl S, Schmitt E, Innerhofer S, Maier M, Gruber-Woelfler H, Khinast J. Crystallization of APIs in a Continuously Seeded Tubular Crystallizer Particle shape and size have an influence on the solubility of an API-particle and on the bioavailability of the substance.
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