Abstract
The first results regarding the crystallization kinetics of the pure semisynthetic β-lactam antibiotic (SSA) ampicillin in water are presented. The experimentally obtained results at pH = 5 and T = 298 K are described well by the population-based crystallization model presented in this paper. The nucleation rate J (# m-3 s-1) is related to the supersaturation ratio of ampicillin S by J = 2 × 107 exp[−3.383/(ln(S))2]. The surface energy γ of creating a nucleus of ampicillin molecules therefore equals 5.83 mJ m-2. The growth rate G (m s-1) is determined with a newly developed adapted single-crystal growth rate analysis method and is related to the supersaturation ratio of ampicillin S by G = 4.57 × 10-8(S − 1)1.72.
Sign-in/Register to access full text options 
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
