Abstract
Crystallization-based isolation of rutin from a plant extracts of Sophora Japonica was studied. Solid-liquid phase equilibria of rutin were determined in methanol, ethanol and 2-propanol. Solvate formation and phase stability were investigated using X-ray powder diffraction and thermogravimetric analysis coupled with differential scanning calorimetry. The experiments revealed a short-term stability of rutin ethanolate at ambient conditions in contrast to the rutin trihydrate phase, which was found to be stable. Based on the particular solubility behavior of both solvate phases in ethanol a seeded crystallization process in batch and semi-continuous operation mode was designed and successfully performed. Crystalline rutin trihydrate of 99% purity was isolated with overall process yields of 95% and 87% in the batch and semi-continuous processes, respectively. Due to their cost-efficiency and robustness the purification processes are attractive to be applied directly in the countries, where the plants are gr...
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