Abstract
AbstractRefractile crystalline deposits in the retina may be a manifestation of drug toxicity.The five drugs known to produce this side effect are: (1)Tamoxifen‐non steroidal estrogen antagonist used in the treatment of breast cancer. (2)Canthaxanthine‐tanning agent for skin pigmentation in vitiligo and for the treatment of photosensitivity in psoriasis and erythrotic porphyrias. (3)Crashed tablets of Methadone, Mepiridine hydrochloride and Methylphenylate that are injected intravenously in drug abusers‐Talc Retinopathy. (4)Methoxyflurane‐an inhalational anesthetic agent . (5)Nitrofurantoin‐an antibiotic used in the treatment of urinary tract infections. Daily doses and cumulative doses that give rise to these deposits will be presented and the fundus/clinical features of each drug as well. Since primary ocular disorders (Bietti's crystalline retinopathy, idiopathic parafoveal telengiectasis, calcified macular drusen) and systemic disorders (oxalosis, cystinosis,Sjogren Larsson syndrome) are known to be associated with crystals in the retina,the differential diagnosis of this clinical entity will be discussed.
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