Abstract

A patient exposed for years to tricalcium phosphate in the dust of a dentifrice died from alveolar adenocarcinoma. Micron-sized crystals of the salt were found in normal, inflamed, granulomatous and neoplastic areas in the viscera and in the mildly inflamed myocardium and pericardium. Excepting neoplastic changes, similar but severer lesions were induced experimentally in rats after ingestion of massive amounts of tricalcium phosphate, alpha quartz, barium sulfate, bismuth subcarbonate, and magnesium trisilicate. Particles of those substances appeared systemically and in the congested myocardium and pericardium with or without inflammation.

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