Abstract
The title compounds, C12H12ClN5OS, (I), and C12H12ClN5OS, (II), are 2-[(di-amino-pyrimidin-2-yl)sulfan-yl]acetamides. Compound (II), crystallizes with two independent mol-ecules (A and B) in the asymmetric unit. In each of the mol-ecules, in both (I) and (II), an intra-molecular N-H⋯N hydrogen bond forms an S(7) ring motif. The pyrimidine ring is inclined to the benzene ring by 42.25 (14)° in (I), and by 59.70 (16) and 62.18 (15)° in mol-ecules A and B, respectively, of compound (II). In the crystal of (I), mol-ecules are linked by pairs of N-H⋯N hydrogen bonds, forming inversion dimers with an R22(8) ring motif. The dimers are linked via bifurcated N-H⋯O and C-H⋯O hydrogen bonds, forming corrugated layers parallel to the ac plane. In the crystal of (II), the A mol-ecules are linked through N-H⋯O and N-H⋯Cl hydrogen bonds, forming layers parallel to (100). The B mol-ecules are also linked by N-H⋯O and N-H⋯Cl hydrogen bonds, also forming layers parallel to (100). The parallel layers of A and B mol-ecules are linked via N-H⋯N hydrogen bonds, forming a three-dimensional structure.
Highlights
The pyrimidine ring is inclined to the benzene ring by
The title 2-[(4,6-diaminopyrimidin-2yl)sulfanyl] based analogues have been synthesized as antiviral agents against NS2B/NS3 Dengue protease
We report on the syntheses and crystal structures of the title compounds, (I) and (II)
Summary
Diaminopyrimidine derivatives are reported to be therapeutic agents towards anti-cancer activity, selectively inhibiting cFms kinase of M-CSF-dependent myeloid leukemia cells (Xu et al, 2010). They have shown antibacterial activity (Kandeel et al, 1994), are potential antimicrobial (Holla et al., 2006) and anti-AIDS agents (Nogueras et al, 1993) and antiviral agents (Hocková et al, 2003, 2004) and have shown promise as immunosuppressants (Blumenkopf et al, 2002). In this connection, the title 2-[(4,6-diaminopyrimidin-2yl)sulfanyl] based analogues have been synthesized as antiviral agents against NS2B/NS3 Dengue protease. We report on the syntheses and crystal structures of the title compounds, (I) and (II)
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have