Abstract
Each central platinum(II) atom in the crystal structures of chlorido-[dihy-droxybis-(1-imino-eth-oxy)arsanido-κ3 N,As,N']platinum(II), [Pt(C4H10AsN2O4)Cl] (1), and of chlorido-[dihy-droxybis-(1-imino-prop-oxy)arsanido-κ3 N,As,N']platinum(II), [Pt(C6H14AsN2O4)Cl] (2), is coordinated by two nitro-gen donor atoms, a chlorido ligand and to arsenic, which, in turn, is coordinated by two oxygen donor ligands, two hydroxyl ligands and the platinum(II) atom. The square-planar and trigonal-bipyramidal coordination environments around platinum and arsenic, respectively, are significantly distorted with the largest outliers being 173.90 (13) and 106.98 (14)° for platinum and arsenic in (1), and 173.20 (14)° and 94.20 (9)° for (2), respectively. One intra-molecular and four classical inter-molecular hydrogen-bonding inter-actions are observed in the crystal structure of (1), which give rise to an infinite three-dimensional network. A similar situation (one intra-molecular and four classical inter-molecular hydrogen-bonding inter-actions) is observed in the crystal structure of (2). Various π-inter-actions are present in (1) between the platinum(II) atom and the centroid of one of the five-membered rings formed by Pt, As, C, N, O with a distance of 3.7225 (7) Å, and between the centroids of five-membered (Pt, As, C, N, O) rings of neighbouring mol-ecules with distances of 3.7456 (4) and 3.7960 (6) Å. Likewise, weak π-inter-actions are observed in (2) between the platinum(II) atom and the centroid of one of the five-membered rings formed by Pt, As, C, N, O with a distance of 3.8213 (2) Å, as well as between the Cl atom and the centroid of a symmetry-related five-membered ring with a distance of 3.8252 (12) Å. Differences between (2) and the reported polymorph [Miodragović et al. (2013 ▸). Angew. Chem. Int. Ed. 52, 10749-10752] are discussed.
Highlights
Each central platinum(II) atom in the crystal structures of chlorido[dihydroxybis(1-iminoethoxy)arsanido-3N,As,N0]platinum(II), [Pt(C4H10AsN2O4)Cl] (1), and of chlorido[dihydroxybis(1-iminopropoxy)arsanido-3N,As,N0]platinum(II), [Pt(C6H14AsN2O4)Cl] (2), is coordinated by two nitrogen donor atoms, a chlorido ligand and to arsenic, which, in turn, is coordinated by two oxygen donor ligands, two hydroxyl ligands and the platinum(II) atom
One intramolecular and four classical intermolecular hydrogen-bonding interactions are observed in the crystal structure of (1), which give rise to an infinite three-dimensional network
Arsenic trioxide was approved by the FDA in 2000 for the treatment of acute promyelocytic leukemia, and since several studies have shown that the combinatorial employment of arsenic and platinum-based cancer drugs has shown significant therapeutic potential (Wang et al, 2004; Shen et al, 2004; Emadi & Gore, 2010; Zhang et al, 2009, 2010)
Summary
Platinum and arsenic compounds have shown great versatility in terms of applications in the biological and medicinal fields (Reedijk, 2009). Arsenic trioxide was approved by the FDA in 2000 for the treatment of acute promyelocytic leukemia, and since several studies have shown that the combinatorial employment of arsenic and platinum-based cancer drugs has shown significant therapeutic potential (Wang et al, 2004; Shen et al, 2004; Emadi & Gore, 2010; Zhang et al, 2009, 2010) These results led to the synthesis of complexes containing both platinum and arsenic (Swindell et al, 2013; Miodragovicet al., 2013, 2019), which were called arsenoplatins. The search revealed that (2) represents a polymorph, with the first crystal structure determination (ODOGOF; Miodragovicet al., 2013) in the orthorhombic space group type Pbca, in contrast to space group type P21/c of (2)
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