Abstract
Neisseria gonorrhoeae is an obligate human pathogen and the causative agent of the sexually-transmitted disease gonorrhea. The control of this disease has been compromised by the increasing proportion of infections due to antibiotic-resistant strains, which are growing at an alarming rate. The MtrCDE tripartite multidrug efflux pump, belonging to the hydrophobic and amphiphilic efflux resistance-nodulation-cell division (HAE-RND) family, spans both the inner and outer membranes of N. gonorrhoeae and confers resistance to a variety of antibiotics and toxic compounds. We here report the crystal structure of the inner membrane MtrD multidrug efflux pump, which reveals a novel structural feature that is not found in other RND efflux pumps.
Highlights
Neisseria gonorrhoeae is a Gram-negative obligate human pathogen
We here report the crystal structure of the inner membrane MtrD multidrug efflux pump, which reveals a novel structural feature that is not found in other RND efflux pumps
To elucidate the mechanism used by this efflux system for multidrug recognition and extrusion, we here describe the crystal structure of the inner membrane MtrD multidrug efflux pump
Summary
Neisseria gonorrhoeae is a Gram-negative obligate human pathogen. It is the causative agent of the sexually-transmitted disease gonorrhea and rare cases of disseminated disease. This article is available at Iowa State University Digital Repository: http://lib.dr.iastate.edu/physastro_pubs/168 We here report the crystal structure of the inner membrane MtrD multidrug efflux pump, which reveals a novel structural feature that is not found in other RND efflux pumps.
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