Abstract
The title compound, C30H44O3 [systematic name: 6aR,6 bR,8aS,9aR,12aR,14bR)-4,4,6a,6;b,8a,14b-hexa-methyl-12-methyl-eneicosa-hydro-3H-phenanthro[1',2':6,7]indeno-[2,1-b]furan-3,11(2H)-dione], is a triterpene lactone, which was isolated from di-chloro-methane extract of Elaeodendron trichotomum (Turcz.) Lundell (celastraceae) stem bark. The compound has a lupane skeleton and consists of four fused six-membered rings and two five-membered rings. In the crystal, mol-ecules are linked by weak C-H⋯O hydrogen bonds into a three-dimensional network. The configuration of ochraceolide A was proposed based on analogue compounds which belong to the lupane type.
Highlights
Molecules are linked by weak C—H O hydrogen bonds into a threedimensional network
The configuration of ochraceolide A was proposed based on analogue compounds which belong to the lupane type
Ochraceolides A–E are a group of cytotoxic lupane -lactones isolated from the Celastraceae family
Summary
Ochraceolides A–E are a group of cytotoxic lupane -lactones isolated from the Celastraceae family. Ochraceolide A was firstly isolated from Kokoona ochracea (Elm.) Merril stem bark (Ngassapa et al, 1991) and afterwards from Lophopetalum wallichii (Sturm et al, 1996) and Cassine xylocarpa (Callies et al, 2015). Ochraceolide A is part of the structure of the Diels–Alder adduct (i.e. celastroidine A or volubilide) isolated from Hippocratea celastroides K. (Alvarenga et al, 2000) In these publications, the crystal structure of the adduct was reported as a solvate of dichloromethane and toluene, respectively. Symmetry codes: (i) x þ 12; y þ 1; z þ 12; (ii) x 1; y þ 12; z þ 52
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