Abstract
The crystal structure of fosfomycin tromethamine has been solved and refined using synchrotron X-ray powder diffraction data, and optimized using density functional techniques. Fosfomycin tromethamine crystallizes in space group P1 (#1) with a = 6.20421(6), b = 9.00072(7), c = 10.91257(15) Å, α = 93.4645(5), β = 101.9734(3), γ = 99.9183(2)°, V = 584.285(2) Å3, and Z = 2. A network of discrete hydrogen bonds links the cations and anions into layers parallel to the ab-plane. The outer surfaces of the layers are composed of the methyloxirane rings of the anions and the methylene groups of the cations. Furthermore, 93% of the atoms are consistent with an additional (pseudo)center of symmetry. The powder pattern has been submitted to ICDD® for inclusion in the Powder Diffraction File™.
Highlights
Fosfomycin is a broad-spectrum antibiotic produced by certain Streptomyces species, and can be made synthetically
Fosfomycin was discovered in a joint research project of Merck & Co. and Compañia
The tromethamine salt of fosfomycin is sold under the brand name Monurol®, prescribed to treat bacterial bladder infections, including acute cystitis or lower urinary tract infections in women
Summary
Fosfomycin is a broad-spectrum antibiotic produced by certain Streptomyces species, and can be made synthetically. The powder diffraction data for fosfomycin tromethamine have been reported by Huang et al Figure [1], no diffraction crystal structure information was carried out as part Diffraction project to determinepowder the crystal structures of large-volume commercial pharmaceuticals, include
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