Abstract
In the title compound, C16H23N3O3S, the dihedral angles between the thiophene ring and the almost planar dimethylamino-methyleneamino (r.m.s. deviation = 0.005 Å) and dimethylamino-acryloyl (r.m.s. deviation = 0.033 Å) substituents are 6.99 (8) and 6.69 (7)°, respectively. The ester CO2 group subtends a dihedral angle of 44.92 (18)° with the thiophene ring. An intramolecular C—H⋯O hydrogen bond generates an S(6) ring. In the crystal, inversion dimers linked by pairs of C—H⋯O hydrogen bonds generate R 2 2(14) loops. In addition, a weak C—H⋯π interaction is observed.
Highlights
C16H23N3O3S, the dihedral angles between the thiophene ring and the almost planar dimethylamino-methyleneamino (r.m.s. deviation = 0.005 Å) and dimethylamino-acryloyl (r.m.s. deviation = 0.033 Å) substituents are 6.99 (8) and 6.69 (7), respectively
Substituted thiophene derivatives are well known for their chemotherapeutic applications (Mabkhot et al, 2013; Mishra et al, 2011)
The H atoms were placed at calculated positions in the riding-model approximation with C—H = 0.96° A, 0.97 ° A and
Summary
C16H23N3O3S, the dihedral angles between the thiophene ring and the almost planar dimethylamino-methyleneamino (r.m.s. deviation = 0.005 Å) and dimethylamino-acryloyl (r.m.s. deviation = 0.033 Å) substituents are 6.99 (8) and 6.69 (7) , respectively. The ester CO2 group subtends a dihedral angle of 44.92 (18) with the thiophene ring. An intramolecular C—H O hydrogen bond generates an S(6) ring. Inversion dimers linked by pairs of C—H O hydrogen bonds generate R22(14) loops. Absorption correction: multi-scan (SADABS; Bruker, 1998)
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