Abstract
The title compound, C14H15FN2O2S, crystallizes with two molecules in the asymmetric unit. In each molecule, the pyrimidine ring adopts a sofa conformation with the sp 3-hybridized C atom forming the flap and the fluoro-substituted ring in an axial position. In the crystal, molecules are linked via N—H⋯S hydrogen bonds, forming chains of R 2 2(8) rings along [100]. In one independent molecule, an intramolecular C—H⋯O hydrogen bond is observed.
Highlights
The title compound, C14H15FN2O2S, crystallizes with two molecules in the asymmetric unit
DHPMs have recently emerged as important target molecules because of their therapeutic and pharmacological properties (Kappe, 2000), such as antiviral (Hurst & Hull, 1961), antimitotic (Mayer et al, 1999), anticarcinogenic and antihypertensive (Atwal et al, 1991)
The bond lengths and bond angles are in good agreement with the corresponding bond distances and angles reported in closely related structures (Qin et al, 2006; Krishnamurthy & Begum, 2015)
Summary
The title compound, C14H15FN2O2S, crystallizes with two molecules in the asymmetric unit. The pyrimidine ring adopts a sofa conformation with the sp3hybridized C atom forming the flap and the fluoro-substituted ring in an axial position. Molecules are linked via N—H S hydrogen bonds, forming chains of R22(8) rings along [100].
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