Abstract
Crystal Structure of a Bony Fish β2-Microglobulin: INSIGHTS INTO THE EVOLUTIONARY ORIGIN OF IMMUNOGLOBULIN SUPERFAMILY CONSTANT MOLECULES
Highlights
Three-dimensional structures of 2-microglobulin (2m) from chicken and various mammals have been described previously, but aside from genomic sequences, very little is known about the three-dimensional structures of 2m in species other than warm-blooded vertebrates
2-microglobulin (2m)3 is classified as part of the set of immunoglobulin superfamily (IgSF) constant (C) proteins based on its amino acid sequence, number of strands, and folding topology [1, 2]
One form is composed of IgSF domains, comprising the B cell receptor, the major histocompatibility complex (MHC) and the T cell receptor (TCR), in which IgSF C is combined with the IgSF variable (V) domain [3]
Summary
2m (Ctid-2m) gene [17]. We resolved the first three-dimensional structure of Ctid-2m at 2.1. Å. Ctid-2m closely resembles the previously described human and bovine monomeric 2m structures, with some significant variations
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