Abstract
The title compound, [Ge(CH3)3(C7H5O2)], was obtained as a by-product in the synthesis of the corresponding aldehyde. Two slightly different mol-ecules are present in the asymmetric unit. In both mol-ecules, the geometry of the aromatic ring plane is distorted by varying intensities. Additionally, the Ge atoms deviate from the mean aromatic ring planes. Whereas the distance of the Ge atom to the ring plane is only 0.101 (4) Å in the first mol-ecule, this distance is increased to 0.210 (4) Å in the second. In the crystal structure, centrosymmetric O-H⋯O hydrogen-bonded dimers are formed. The title compound is isostructural with the Si analogue [Haberecht et al. (2004 ▶). Acta Cryst. E60, o329-0330].
Highlights
The title compound, [Ge(CH3)3(C7H5O2)], was obtained as a by-product in the synthesis of the corresponding aldehyde
Two slightly different molecules are present in the asymmetric unit
The geometry of the aromatic ring plane is distorted by varying intensities
Summary
The application of 1,4-dihydropyridines (DHPs) as a pharmaceutical tool represents a novel and promising approach in the therapy of autoimmune diseases, cancer and other illnesses. The effect of drugs containing DHPs is based on the interaction with the Transforming Growth Factor (TGF). The title compound, [Ge(CH3)3(C7H5O2)], (I), was obtained as a side-product in the synthesis of the corresponding aldehyde, which can be employed in the synthesis of DHPs (Längle et al, 2015)
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