Abstract
In the title compound C27H22Cl2N4O2, the pyrazol-5-ol ring makes a dihedral angle of 34.80 (11)° with the phenyl ring to which it is bound, while the pyrazolone ring is inclined at 34.34 (12)° to its attached phenyl ring. In the crystal, N—H⋯O and C—H⋯Cl hydrogen bonds link the molecules into chains along [010]. Intermolecular π–π interactions are observed between the pyrazolone ring and the phenyl ring bound to the pyrazol-5-ol ring system [centroid–centroid separation = 3.916 (2) Å].
Highlights
In the title compound C27H22Cl2N4O2, the pyrazol-5-ol ring makes a dihedral angle of 34.80 (11) with the phenyl ring to which it is bound, while the pyrazolone ring is inclined at
Intermolecular – interactions are observed between the pyrazolone ring and the phenyl ring bound to the pyrazol-5-ol ring system [centroid–centroid separation = 3.916 (2) Å]
Bis-pyrazolones are an important class of heterocyclic compounds which have risen to prominence in recent years due to their vital role in various biological activities such as selective COX-2 inhibition, antitumor and cytokine inhibition (Park et al, 2005)
Summary
In the title compound C27H22Cl2N4O2, the pyrazol-5-ol ring makes a dihedral angle of 34.80 (11) with the phenyl ring to which it is bound, while the pyrazolone ring is inclined at. Tawi 180 006 , India, and bDepartment of Chemistry, University of Jammu, Jammu Intermolecular – interactions are observed between the pyrazolone ring and the phenyl ring bound to the pyrazol-5-ol ring system [centroid–centroid separation = 3.916 (2) Å]. Absorption correction: multi-scan (CrysAlis PRO; Agilent, 2013)
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