Crystal structure of 2-amino-N-(2-fluoro-phen-yl)-4,5,6,7-tetra-hydro-1-benzo-thio-phene-3-carboxamide.

K Chandra Kumar,B M Rajesh,V Umesh,Chandra Chandra,T K Madhura

doi:10.1107/s2056989015018022

K Chandra Kumar, B M Rajesh + Show 3 more

Open Access

https://doi.org/10.1107/s2056989015018022

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Abstract

In the title compound, C15H15FN2OS, the dihedral angle between the planes of the benzothiophene ring system and the fluorobenzene ring is 3.74 (14)°. The six-membered ring of the benzothiophene moiety adopts a half-chair conformation. The molecular conformation is consolidated by intramolecular N—H⋯F and N—H⋯O hydrogen bonds. In the crystal, molecules are linked by N—H⋯O hydrogen bonds, generating C(6) [001] chains.

Highlights

In the title compound, C15H15FN2OS, the dihedral angle between the planes of the benzothiophene ring system and the fluorobenzene ring is 3.74 (14)
Thiophene nucleus has been established as a potential entity in the largely growing chemical world of heterocyclic compounds possessing promising pharmacological characteristics such as anti-HIV PR inhibitors (Bonini et al, 2005)
In addition structures containing fluorine atoms plays a major role in intermolecular interactions (Choudhury et al, 2004)

Summary

Introduction

C15H15FN2OS, the dihedral angle between the planes of the benzothiophene ring system and the fluorobenzene ring is 3.74 (14) . The six-membered ring of the benzothiophene moiety adopts a half-chair conformation. Molecules are linked by N—H O hydrogen bonds, generating C(6) [001] chains. H-atom parameters constrained max = 0.20 e Å3 (2005); Brault et al (2005); Isloor et al (2010).

Results

Conclusion