Abstract
Problem statement: The studied dihydropyridone was synthesized for the first time via the microwave assisted reaction of curcumin and methylamine and it is important to support the mechanism by the crystal structure. Approach: The crystal structure of the title compound was determined using high resolution x-ray diffraction. PowderSolve program was used to solve the structure while the refinement was done in material studio Reflex module. Results: The findings obtained with high-resolution x-ray powder diffraction and molecular location methods based on simulated annealing algorithm after Rietveld refinement showed that the monoclinic unit cell was a = 13.4925 Å b = 12.8162 Å, c = 11.5231 Å, α = 90.000°, β= 99.0401°,γ = 90.000°; cell volume = 1967.85Å3 and space group P 21/a with 4 molecules in a unit cell. Conclusion/Recommendations: Powder diffractometry could be a powerful tool for determining crystal structures for organic molecules.
Highlights
Dihydropyridones are important intermediates for synthesis of natural products, alkaloids and many approaches to their synthesis have been developed (Donohoe et al, 2009; Comins and Ollinger, 2001; Song et al, 2007; Saito et al, 2009; Dieter and Guo, 2009; MacDonald and Burnell, 2009)
In a previous study (Elias et al, 2008) we reported the synthesis of a series of dihydropyridones that structurally related to that synthesized by Sugiyama et al (1970), by the reaction of curcumin and amines or amine acetates under microwave irradiation in an approach that seems unexpected
The compound was synthesized according to previously described procedure (Elias et al, 2008)
Summary
Dihydropyridones are important intermediates for synthesis of natural products, alkaloids and many approaches to their synthesis have been developed (Donohoe et al, 2009; Comins and Ollinger, 2001; Song et al, 2007; Saito et al, 2009; Dieter and Guo, 2009; MacDonald and Burnell, 2009). Dihydro-1, 2-diphenyl-6-(2-phenylethenyl)-4-pyridone from the reaction of 6-methyl-1, 2-diphenyl-2, 3-. In a previous study (Elias et al, 2008) we reported the synthesis of a series of dihydropyridones that structurally related to that synthesized by Sugiyama et al (1970), by the reaction of curcumin and amines or amine acetates under microwave irradiation in an approach that seems unexpected. The compound is yellow powder and difficult to crystallize. Powder x-ray diffraction is the method of choice for characterizing the structures if solids are not available as suitable single crystals. Structure Determination from Powder Diffraction (SDPD) has matured into a technique that is widely and successfully used in the context of organic, inorganic and organometallic compounds (David and Shankland, 2008; Bail, 2005).
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
