Crystal structure of 1 l-1,2:4,5-di- O-isopropylidene- allo-inositol; A comparison of its conformation in solid and solution states

Abstract

The X-ray crystal structure of 1 l-1,2:4,5-di- O-isopropylidene- allo-inositol, is described. The inositol ring deviate slightly from the ideal chair conformation to a flattened chair. A comparison of its conformation in solution with that in solid was made by the use of 1H NMR. This conformational analysis revealed that the title compound adopts similar conformations in solid state and in solution in low polar solvents like benzene and CHCl 3 while in high polar solvents such as Me 2SO, the solid state conformation is not retained.