Crystal Structure and Biological Evaluation of Two Novel Organic-Inorganic Hybrid Materials as Antitumor Agents in the Treatment of Liver Cancer

Bao-Hua Song,Gui-Feng An,Chen Li

doi:10.1155/2018/9758197

Bao-Hua Song, Gui-Feng An + Show 1 more

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https://doi.org/10.1155/2018/9758197

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Abstract

Two novel organic-inorganic hybrid materials {(Hbiz)6[AsIII2AsVMoVI18O62]}·H2O (1, biz = benzimidazole) and (dim)[AsIII2AsVMoVI18O62] [2, dim = 1,6-bis(imidazol)hexane] have been successfully obtained by using the molybdenum arsenate and different N donor organic compounds and determined through X-ray single-crystal diffraction technique. The in vitro cytotoxicity of compounds 1 and 2 was then investigated against three human liver tumor cell lines (SMMC7721, Bel-7402, and MHCC97) by MTT assay. It was found that the two compounds showed potent use as antitumor agents against the aforementioned cell lines.

Highlights

Despite remarkable progress in the evolution of biological medicine field and understanding of the origin of the de diseases, the scientists fail to obtain effective methods for treating some diseases such as cancer
In spite of great efforts currently being devoted to the creation of therapeutic tools, current effective therapeutic is limited to chemotherapy, which is the dominant treatment method
The creation of effective chemotherapy drugs with low cost, high selectivity, undesirable side effects, and low cytotoxicity is of high importance [2, 3]. e cancer cell resistance to anticancer agents and the toxicity of modern chemotherapy make the sciences worldwide search for new drugs and cure methods for such an insidious disease [4]

Summary

Introduction

Despite remarkable progress in the evolution of biological medicine field and understanding of the origin of the de diseases, the scientists fail to obtain effective methods for treating some diseases such as cancer. Two novel organicinorganic hybrid materials {(Hbiz)6[As2Mo18O62]}·H2O (1, biz benzimidazole) and (dim)[AsIII2AsVMoVI18O62] (2, dim 1,6-bis(imidazol)hexane) have been successfully obtained by using the molybdenum arsenate and different N donor compounds (Figure 1) under hydrothermal conditions and their corresponding antitumor performance was subsequently studied. An Oxford Xcalibur E diffractometer was Journal of Chemistry employed to collect the single crystal X-ray diffraction data.

Results

Conclusion