Crystal structure and anti-cancer activity on retinoblastoma of an In(III)—Na(I) coordination polymer based on flexible 4,4′-dithiodibenzoic acid

Abstract

A bimetallic coordination polymer is prepared via a hydrothermal reaction of H2DDBA and In(NO3)3 in water with NaOH as a pH regulator. Its chemical formula is [In2Na(H2O)6(ddba)3]·(NO3)(H2O)7 (1, H2ddba = 4,4'-dithiodibenzoic acid). The composition and atomic arrangement of the prepared complexes are studied by the elemental analysis (EA) and the thermogravimetric analysis (TGA), powder and single crystal X-ray diffraction measurements. Moreover, a process of sonochemistry with oleic acid treatment at 453 K is used to produce nano­structure 1. In the biological function detection, a miRNA relative expression is detected via RT-PCR and Bcl-2 expression level is determined with the Western blot. The Annexin V-FITC/PI staining is performed to detect retinoblastoma cell apoptosis after treatment with nano-1.