Abstract
Curcumin is a pharmaceutically viable ingredient derived from the rhizome of the Indian spice turmeric (Curcuma longa). However, curcumin suffers from poor water solubility, which limits its bioavailability. In this work, we report studies carried out to investigate cocrystallization of curcumin to improve its aqueous solubility. Salicylic acid and hydroxyquinol were used as coformers. Binary phase diagrams were constructed for curcumin–salicylic acid and curcumin–hydroxyquinol systems using differential scanning calorimetric (DSC) thermograms obtained for mixtures prepared by solid-state grinding. The curcumin–salicylic acid system was found to form an eutectic at a curcumin mole fraction of 0.33, whereas the curcumin–hydroxyquinol system clearly exhibited a cocrystal forming region. Out of the several curcumin to hydroxyquinol ratios studied, cocrystal formation was observed for mixtures containing curcumin mole fractions of 0.33 and 0.5. These curcumin–hydroxyquinol cocrystals were further characterize...
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