Abstract
Abstract The crystal and molecular structures of two closely related antiviral purine derivatives are reported. In 9-[4-hydroxy-3-(hydroxymethyl)butyl]guanine (2) the plane of the acyclic N9 substituent is orthogonal to the purine ring. In crystals of 2 there is an extensive network of intermolecular hydrogen bonds. In 9-[4-acetoxy-3-(acetoxymethyl)butyl]-2-aminopurine (3) characteristic changes in the geometry of the pyrimidine ring in comparison with 2 are observed. In crystals of the 2-aminopurine derivative 3 there is an absence of major hydrogen bonding interactions and there are π-π interactions between parallel overlapping pyrimidine moieties.
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