Abstract
The vesicular drug delivery systems are promising approaches to overthrown the problems of drugs having lesser bioavailability and rapid elimination from the body. The four type of lipid based drug delivery systems are: solid-lipid particulate system, emulsion based system, solid lipid tablet and vesicular system. Cryptosomes, a novel emerging vesicular drug delivery system which can overcome the disadvantages associated with conventional drug delivery systems like high stability, increased bioavailability, sustained release, decreased elimination of rapidly metabolizable drugs etc. The word Cryptosome was orginated from Greek word ‘’Crypto’’ means hidden and ‘’Soma’’ means body. It is formed from the mixture of phospholipids like distearoyl phosphatidyl ethanolamine-polyethylene glycol (DSPE-PEG) with distearoylphosphatidylcholine. These entire information regarding its origin and formation is explained in Dinesh Kumar et al. Vesicular systems symbolizes the use of vesicles in the different fields as carrier system or additives. This review disclose various vesicular drug delivery system and point out the advancement of cryptosome in the world of drug delivery.This review would help researchers involved in the field of vesicular drug delivery.
Highlights
In the present scenario of drug discovery systems, various drug delivery systems are introduced to enhance the therapeutic activity and to reduce the adverse effect of various new drugs, one such drug delivery system is Cryptosomes
This system enabled a remarkable growth in drug discovery, development, and use
The lipid based drug delivery systems (LDDS) is classified into four types, including the solid lipid particulate dosage form, emulsion based system, solid lipid tablets and vesicular systems
Summary
In the present scenario of drug discovery systems, various drug delivery systems are introduced to enhance the therapeutic activity and to reduce the adverse effect of various new drugs, one such drug delivery system is Cryptosomes. The term Cryptosomes was derived from the Greek word Crypto means hidden and Soma means body or carrier This lipid vesicle circulate in blood for long period of time after systemic applications and have decreased phagocyte mononuclear uptake [3, 4]. Positively charged lipids are used as they exhibit increased biodegradability and stability in blood They are lipid malleable vesicle embedding permeation enhancer formed by phospholipid, ethanol and water. It exhibit high stability, enhanced drug entrapment They act as efficient ligand-mediated drug delivery system. The most commonly used phospholipid in the formulation is phosphatidylcholine, it form the elementary unit of plasma membrane, it act as a safeguard of polyphenolics, and it exhibit both hydrophilic and lipophilic analogs, the phosphatidyl moiety being lipophilic and choline moiety being hydrophilic nature [53]
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