Abstract
IN RECENT years, infection by Cryptococcus neoformans has received increased attention. Although infection with this agent commonly occurs in the compromised host, approximately 50% of cases occur in healthy individuals. 1 The most commonly recognized form of cryptococcal disease is chronic meningitis. While the respiratory tract is the usual portal of entry of the organism, relatively few reports of pulmonary cryptococcal disease have appeared in the literature, and cases of primary pulmonary infection are recognized infrequently. Pleural infection appears to be recognized even less commonly. We describe a patient with widespread Hodgkin disease who developed fatal disseminated infection with C neoformans manifested by meningitis and predominant pleuropulmonary involvement. Report of a Case In July 1971, a 21-year-old man was seen with cervical adenopathy. Biopsy showed Hodgkin disease of mixed cellularity type, and it was subsequently classified as stage IA. He received radiotherapy to the right side of the neck. In
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