Abstract
Detection of cryptococcal antigen (CrAg) in serum or plasma is a sensitive predictor of cryptococcal meningitis (CM). Retrospective observations suggest that routine CrAg screening and preemptive antifungal therapy for those who are positive could prevent subsequent CM. To examine the effect of CrAg screening prospectively, 645 antiretroviral therapy (ART)-naive, HIV-infected patients with peripheral blood CD4 cell counts ≤100/µL in two South African clinics were screened for CrAg, first by serum latex agglutination (LA) …
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