Abstract
Cold has been a treatment method in medicine for thousands of years. For the past century, cryosurgery has been used in the treatment of a wide variety of cutaneous lesions. Several instruments with different techniques are available to the clinician who practices cryosurgery. Cold causes tissue damage via several mechanisms, including direct tissue destruction and the induction of an immune response. Benign, premalignant, and malignant cutaneous lesions can be successfully treated with cryosurgery, although the clinician must consider every case and each patient individually in assessment of the appropriate use of cryotherapy. Some lesions that may be successfully treated with cryosurgery are verrucae, seborrheic keratoses, granuloma annulare, lentigines, keloids, prurigo nodularis, psoriasis, myxoid cysts, condylomata acuminata, actinic keratoses, lentigo maligna, squamous cell carcinoma, basal cell carcinoma, and Kaposi's sarcoma. Cryosurgery does have associated side effects and complications. The clinician must be aware of these so that proper management can be instituted.
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