Abstract
AbstractCryoglobulinemia is characterized by the presence of cryoglobulins in the serum. Cryoglobulinemic vasculitis can show involvement of skin, joints, kidney, peripheral nerves, etc. Cryoglobulinemic glomerulonephritis is seen in patients with type II (hepatitis C, connective tissue disorders) and type III (chronic hepatitis B and C, mixed connective tissue diseases) mixed cryoglobulinemia and in patients with type I cryoglobulinemia with monoclonal IgG3 or IgG1 (associated with MGUS, lymphoma or multiple myeloma). Cryoglobulinemic glomerulonephritis is most commonly seen in the setting of type II cryoglobulinemia. These patients can have reduced serum C3 and C4 levels.
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