Abstract
Avascular necrosis of femoral head (ANFH) is a disease that is characterized by structural changes and collapse of the femoral head. The exact causes of ANFH are not yet clear, but small advances in etiopathogenesis, diagnosis and treatment are achieved. In this study, ß-tricalcium phosphate/poly lactic-co-glycolic acid composite scaffolds incorporated with bisperoxovanadium [bpV (pic)] (bPTCP) was fabricated through cryogenic 3D printing and were utilized to treat rat models with early ANFH, which were constructed by alcohol gavage for 6 months. The physical properties of bPTCP scaffolds and in vitro bpV (pic) release from the scaffolds were assessed. It was found that the sustained release of bpV (pic) promoted osteogenic differentiation and inhibited adipose differentiation of bone marrow-derived mesenchymal stem cells. Micro-computed tomography scanning and histological analysis confirmed that the progression of ANFH in rats was notably alleviated in bPTCP scaffolds. Moreover, it was noted that the bPTCP scaffolds inhibited phosphatase and tensin homolog and activated the mechanistic target of rapamycin signaling. The autophagy induced by bPTCP scaffolds could partially prevent apoptosis, promote osteogenesis and angiogenesis, and hence eventually prevent the progression of ANFH, suggesting that the bPTCP scaffold are promising candidate to treat ANFH.
Highlights
Avascular necrosis of femoral head (ANFH) is a disease that is related to necrosis of bone cells and marrow tissue, structural changes and collapse of the femoral head, joint dysfunction and pain (Seijas et al, 2017)
It can be seen that the distinctive peaks at 1,631 and 805 cm−1 were corresponding to the–OH stretching vibrations of TCP/PLGA, intimating that there is–OH group existing on the surface of the scaffolds
The C-H, C-O, C O and–OH peaks area of TCP/PLGA tended to a lower peak area and the vibration band at 1,238 cm−1 presented the C N stretching bands, The vibration band at 1,045 cm−1 presented the C-N stretching bands, revealing that there was an incorporation between the TCP/PLGA material and bpV
Summary
Avascular necrosis of femoral head (ANFH) is a disease that is related to necrosis of bone cells and marrow tissue, structural changes and collapse of the femoral head, joint dysfunction and pain (Seijas et al, 2017). ANFH is a slow-course disease with complex etiology and a high disability rate, leading to the loss of a patient’s physical labor ability (Zalavras and Lieberman, 2014). China have the custom of drinking a high dose of alcohol for a long time, the incidence of ANFH has been increasing year by year (Cui et al, 2015). The most effective surgical approach for ANFH is total hip arthroplasty (THA), but due to the limited lifetime of the artificial joints, it is still controversial (Scaglione, 2015). Developing a novel treatment strategy for ANFH is of great importance and demand
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